Which Statement Best Describes Appraisal of Research Evidence

Which statement best describes appraisal of research evidence?

A) Appraisal is a critique of the weaknesses of a clinical practice guideline, systematic review, or study.
B) Appraisal is a careful personal judgment regarding the generalizability of the recommendations of clinical practice guidelines, conclusions of systematic reviews, or study findings.
C) Appraisal is the opinion of an expert in the field regarding the methodological soundness of a clinical practice guideline, systematic review, or study.
D) Appraisal is a set of judgments using an objective set of criteria regarding the credibility, clinical significance, and applicability of the recommendations of clinical practice guidelines, conclusions of systematic reviews, or study findings.