Which of the Following Questions Is Part of Appraising the Credibility

Which of the following questions is part of appraising the credibility of a systematic review?

A) What topic or question did the systematic review address?
B) Was the search for study reports comprehensive and unbiased?
C) Is the size of the clinical effect large enough to make a difference in patient well-being?
D) Are there any reasons why the conclusions might not apply to your setting?