A Man with Renal Stones Is Found to Have Hypercalciuria

A man with renal stones is found to have hypercalciuria. The drug most likely used to treat this condition blocks which step in nephron function?

A) conversion of bicarbonate to carbon dioxide
B) sodium chloride reabsorption from the distal tubule
C) expression of sodium channel protein in the collecting duct
D) sodium chloride reabsorption from the loop of Henle
E) sodium-potassium exchange in the collecting duct