Why would polymorphisms of the OAT1B1 protein lead to liver cell hypersensitivity and polymorphisms of the MRP2 protein lead to liver cell hyposensitivity to the cholesterol lowering drug pravastatin?

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Quizplus · Accepted Answer

The Answer is OATP1B1 transported polymorphisms leads to increased plasma concentrations of the metabolite and toxicity of the statins. The opposite is true for those with polymorphisms encoding for a the multidrug resistance-associated protein 2.

Why Would Polymorphisms of the OAT1B1 Protein Lead to Liver