Following the discovery of leptin as a key satiety signal, what was a reason for it not leading to successful treatment for feeding behavior in obese individuals?

Question

Quizplus · Accepted Answer

Most obese individuals have high levels of leptin due to their larger amount of adipose tissue, but their bodies are resistant to leptin's effects, similar to how type 2 diabetes involves insulin resistance. This means that simply adding more leptin, as in leptin treatment, does not effectively reduce feeding behavior or cause weight loss in most obese individuals because their bodies do not respond to it properly.

Following the Discovery of Leptin as a Key Satiety Signal