Why Are the Physiological Effects of Nitric Oxide (NO) Affected

Why are the physiological effects of Nitric oxide (NO) affected by phosphodiesterase inhibitors?

A) Phosphodiesterase inhibitors prevent re-uptake of NO into cells.
B) Phosphodiesterase inhibitors prolong the lifetime of cGMP.
C) Phosphodiesterase inhibitors prolong the lifetime of cAMP.
D) Phosphodiesterase inhibitors prevent the enzymatic breakdown if NO.
E) Phosphodiesterase inhibitors block the reaction of NO with proteins.