Ionotropic nicotinic acetylcholine receptors are known to excite cells based on the flux of sodium ions into the cell cytoplasm when these channels are activated near resting membrane potential. However, how can the calcium flux through these receptors lead to an inhibitory influence?

Question

Quizplus · Accepted Answer

Calcium entering the cell through nicotinic receptors can activate calcium-activated potassium channels. When these potassium channels open, potassium ions leave the cell, leading to hyperpolarization of the cell membrane. This hyperpolarization makes the cell less likely to fire an action potential, thus having an inhibitory effect on the cell's activity.

Ionotropic Nicotinic Acetylcholine Receptors Are Known to Excite Cells Based