Charged Amino Acid Residues Located at Cytoplasmic and Extracellular Surfaces

Charged amino acid residues located at cytoplasmic and extracellular surfaces of the receptor

A) enable homomultimeric α7 channels even when other subunit isotypes are not present.
B) influence affinity for the bound ligand.
C) influence channel open time.
D) govern cation or anion selectivity of the channel.
E) govern ligand selectivity (e.g., serotonin, glutamate, γ-aminobutyric acid, glycine, or zinc) .