If an Experimenter Wants to Apply a Cytoplasmic Molecule in the Middle

If an experimenter wants to apply a cytoplasmic molecule in the middle of a recording session using a patch clamp experiment to measure the effects of this ligand on ion channels, which experimental approach in most commonly used?

A) Microelectrode recording
B) Whole-cell patch clamp
C) Cell-attached patch clamp
D) Outside-out patch clamp
E) Inside-out patch clamp