The "Outside-Out" Patch Clamp Technique

The "outside-out" patch clamp technique

A) allows the experimenter to easily change the solution bathing the inside surface of the membrane patch during the recording and study the activity of single voltage-gated channel currents.
B) allows the experimenter to easily change the solution bathing the outside surface of the membrane patch during the recording and study the activity of single voltage-gated channel currents.
C) does not allow the experimenter to change the solution on either side of the membrane patch, but you can study the activity of single voltage-gated currents.
D) allows the experimenter to easily change the solution bathing the inside surface of the membrane patch during the recording and study the summed activity of all voltage-gated channels in the cell (macroscopic current) .
E) allows the experimenter to easily change the solution bathing the outside surface of the membrane patch during the recording and study the summed activity of all voltage-gated channels in the cell (macroscopic current) .