Based on your knowledge of MHC I and II, predict which cell type would be MOST likely not to express detectable MHC I.

Question

Quizplus · Accepted Answer

Erythrocytes, or red blood cells, are the most likely not to express detectable MHC I because they lack a nucleus and other organelles in their mature form, making them unique among human cells in this aspect. MHC I molecules are typically present on the surface of all nucleated cells in the body to present endogenous antigens to CD8+ T cells. Since erythrocytes are not nucleated, they do not participate in this antigen presentation pathway.

Based on Your Knowledge of MHC I and II, Predict