Affinity Maturation _____________. (Select All That Apply)

Affinity maturation _____________. (Select all that apply)

A) results from activation of only the memory B cells with the highest affinity receptors
B) may occur by somatic mutations generating antibodies with the same specificity but significantly higher binding affinity
C) is the production of antisera with increasingly higher pathogen affinity
D) results in highly efficient pathogen elimination during secondary immune responses