This antiviral agent is an inhibitor of the HIV protease enzyme. It binds to the active site of HIV protease ~100X more tightly than other protease inhibitors. It is used in combination therapy to treat individuals for whom dolutegravir-based therapies are failing.

Question

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Darunavir is known for its strong binding affinity to the HIV protease enzyme, making it significantly more effective than other protease inhibitors in certain cases. It is specifically used in scenarios where dolutegravir-based therapies are not effective, highlighting its role in combination therapy for HIV treatment.

This Antiviral Agent Is an Inhibitor of the HIV Protease