One dose of a drug is administered that has a half-life of 8 hours.Assuming first-order kinetics,how much time is needed for this drug to be over 96% eliminated from the body?

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Assuming first-order kinetics,40 hours would be required for this drug to be over 96% eliminated from the body.Five half-lives are needed to reduce the levels of a drug to 3.125% of the original levels,or eliminate over 96%.For a drug with an 8-hour half-life,this amounts to five half-lives× 8 hours per half-life,or 40 hours.

One Dose of a Drug Is Administered That Has a Half-Life