Drugs such as selegiline (Eldepryl)and rasagiline (Azilect)that inhibit the monoamine oxidase type B (MAOB)enzyme may be helpful in Parkinson disease because

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MAOB is responsible for the breakdown of dopamine in the brain. Therefore, inhibiting this enzyme with drugs such as selegiline and rasagiline can increase dopamine levels in the brain and improve Parkinson's symptoms. They do not affect dopamine absorption from the GI tract, the conversion of levodopa to dopamine in the bloodstream, or the movement of levodopa across the blood-brain barrier. They also do not affect the breakdown of acetylcholine in the brain.

Drugs Such as Selegiline (Eldepryl)and Rasagiline (Azilect)that Inhibit the Monoamine