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Catechol-O-Methyltransferase (COMT)inhibitors Such as Entacapone (Comtan)and Tolcapone (Tasmar)may Enhance the Effects

Question 1

Multiple Choice

Catechol-O-methyltransferase (COMT) inhibitors such as entacapone (Comtan) and tolcapone (Tasmar) may enhance the effects of levodopa because these drugs


A) decrease the breakdown of dopamine in the brain
B) increase dopamine absorption from the GI tract
C) prevent conversion of levodopa to an inactive metabolite in the bloodstream
D) increase the breakdown of dopamine in the brain
E) prolong the activity of acetylcholine in the brain

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