Tendon pain and inflammation (tendinopathy)that can be severe and ultimately lead to tendon rupture may be caused by

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Fluoroquinolones, such as ofloxacin, have been associated with an increased risk of tendon pain and inflammation, which in some cases have led to tendon rupture. The mechanism is thought to be related to their effects on collagen synthesis and degradation in tendons.

Tendon Pain and Inflammation (Tendinopathy)that Can Be Severe and Ultimately