What occurs in the hypertrophic zone during endochondral ossificiation?
A) Chondrocytes in the center of the cartilage undergo mitosis and growth
B) Invasion of empty lacunae by osteoprogenitor cells
C) Penetration of calcified septa by blood vessels
D) Programmed cell death of chondrocytes
E) Proliferating chondrocytes organize into parallel columns
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