Which of the following could result in the most serious type of mutation?
A) A nucleotide substitution in an exon.
B) A nucleotide deletion in an exon.
C) A nucleotide insertion in an intron.
D) A nucleotide substitution in an intron.
E) More than one of these would be most serious.

Question

Quizplus · Accepted Answer

A nucleotide deletion in an exon can result in a frameshift mutation, which alters the reading frame of the gene and can completely change the amino acid sequence of the resulting protein. This can have serious consequences for the function of the protein and can lead to genetic disorders or diseases. The other options, while still potentially damaging, are less likely to cause such drastic changes in the protein product.

Which of the Following Could Result in the Most Serious