Hereditary nonpolyposis colon cancers (HNPCC)

Question

Quizplus · Accepted Answer

Hereditary nonpolyposis colon cancers (HNPCC) are caused by mutations in DNA repair genes, specifically genes involved in mismatch repair, which increases mutation rates in microsatellite regions. Therefore, option D is the correct answer, which states that HNPCC is caused by mutations in DNA repair genes and increases mutation rates in microsatellite regions. Option A is incorrect because HNPCC is not caused by mutations in tumor-suppressor genes. Option B is partially correct, as HNPCC is caused by mutations in DNA repair genes, but not all DNA repair genes are affected. Option C is also partially correct, as HNPCC does increase mutation rates in microsatellite regions, but it is not the only cause of it.

Hereditary Nonpolyposis Colon Cancers (HNPCC)