This nephrectomy specimen shows a lesion in the kidney of a 63-year-old man. The lesion is most likely related to
A) a deletion of von Hippel-Lindau (VH
L) tumor suppressor gene
B) a mutation of myc oncogene
C) an amplification of ras oncogene
D) a loss of bcl-2 proapoptotic gene
E) an aflatoxin related carcinogen

Question

This nephrectomy specimen shows a lesion in the kidney of a 63-year-old man. The lesion is most likely related to 
A) a deletion of von Hippel-Lindau (VH
L) tumor suppressor gene 
B) a mutation of myc oncogene 
C) an amplification of ras oncogene 
D) a loss of bcl-2 proapoptotic gene 
E) an aflatoxin related carcinogen

Quizplus · Accepted Answer

The kidney contains a large renal cell carcinoma. These tumors contain large amounts of lipids, which accounts for their yellow color on gross examination and the clear appearance of cells in routine microscopic slides. Deletions of the von Hippel-Lindau mutations are found in most clear renal cell carcinomas.

This Nephrectomy Specimen Shows a Lesion in the Kidney of a 63-Year-Old