The monoamine hypothesis of depression is supported by the fact that drugs that increase serotonin and norepinephrine are effective treatments.

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The monoamine hypothesis suggests that depression is caused by a deficiency in certain neurotransmitters, including serotonin and norepinephrine. Drugs that increase the levels of these neurotransmitters, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), have been shown to be effective antidepressants, providing support to the monoamine hypothesis.

The Monoamine Hypothesis of Depression Is Supported by the Fact