Which of the following comparisons between TH1 and TH2 cells is true?
A)TH1 cells produce interleukin (IL)-1 but not IL-2, and TH2 cells produce IL-2 but not IL-1.
B)TH1 cells are class I major histocompatibility complex (MHC) restricted, and TH2 cells are class II MHC restricted.
C)The chemokine receptors CXCR3 and CCR5 are more highly expressed on TH2 cells than on TH1 cells.
D)TH2 cells are more likely to bind to E-selectin and P-selectin on endothelial cells than are TH1 cells.
E)TH1 cells produce interferon (IFN)-ƴ but not IL-4, and TH2 cells produce IL-4 but not IFN-ƴ

Question

Quizplus · Accepted Answer

The signature cytokines of TH1 and TH2 cells are interferon-ƴ and interleukin (IL)-4, respectively. IL-5 and IL-13 are also very specific for TH2 cells. IL-1 is not typically produced by helper T cells of either subset. IL-2 is produced by naive T cells and TH1 cells. Both TH1 and TH2 cells are CD4⁺ helper T cells, and therefore are both restricted to recognizing peptide antigens bound to class II MHC molecules. The trafficking patterns of TH1 and TH2 cells differ, and this is related to differences in the expression of adhesion molecules and chemokine receptors. TH1 cells express abundant functional ligands for E-selectin and P-selectin and the chemokine receptors CXCR3 and CCR5, which bind to various chemokines found at sites of active innate immune responses. TH2 cells bind poorly to endothelial selectins and express less CXCR3 and CCR5.

Which of the Following Comparisons Between TH1 and TH2 Cells