Differentiation of TH2 cells from naive precursor cells is dependent on which of the following?
A)Toll-like receptor (TLR) ligands
B)T-bet
C)Interleukin-12
D)GATA-3
E)Interferon-α

Question

Quizplus · Accepted Answer

GATA-3 is a transcription factor that is expressed during differentiation and is required for TH2 differentiation. T-bet is a protein that regulates genetic changes required for TH1 differentiation. In general, innate immune responses, many of which are stimulated microbial products binding Toll-like receptors (TLRs) on antigen-presenting cells (APCs), promote TH1 differentiation. In part, the positive influence of innate immune responses on TH1 differentiation is mediated by cytokines secreted by activated APCs, including interleukin-12 and type I interferons (IFN-α and IFN-β).

Differentiation of TH2 Cells from Naive Precursor Cells Is Dependent