Which of the following descriptions about affinity maturation is correct?

Question

Quizplus · Accepted Answer

Somatic mutation of V genes is the basis for production of immunoglobulins with different affinities, which are then positively selected in the germinal center; B cells that cannot bind antigen with high affinity die through a default pathway of apoptosis. Antigen processing and presentation by dendritic cells are required to generate helper T cells outside the follicle, but not to activate B cells in the follicle. Autoimmune regulator (AIRE) is involved in thymic expression of tissue antigens but is not involved in affinity maturation. Somatic recombination of V genes is involved in producing functional Ig genes during B cell development, but it is not involved in germinal center reactions.

Which of the Following Descriptions About Affinity Maturation Is Correct