A 47-Year-Old Woman Had a Mastectomy Because She Had Breast

A 47-year-old woman had a mastectomy because she had breast carcinoma that was previously diagnosed by biopsy.Pathologic examination revealed that several axillary lymph nodes contained metastatic tumors.A test was performed on tumor cells extracted from the mastectomy specimen,which indicated that the tumor cells overexpressed a certain cellular proto-oncogene.On the basis of this test result,the patient was treated with an FDA-approved monoclonal antibody specific for the protein encoded by that gene.Which of the following was most likely the protein target of this antibody therapy?

A) p53
B) H-Ras
C) HPV E7
D) Rb
E) Her2