Individuals with the class I HLA-B27 allele have a 90-fold greater chance of developing which of the following inflammatory diseases,relative to HLA-B27-negative individuals?
A)Rheumatoid arthritis
B)Ankylosing spondylitis
C)Pemphigus vulgaris
D)Diabetes mellitus type 1 (insulin dependent)
E)Multiple sclerosis

Question

Quizplus · Accepted Answer

Individuals who are positive for the class I HLA-B27 allele have a 90- to 100-fold greater chance of developing ankylosing spondylitis than do individuals lacking B27.This constitutes the strongest HLA disease association thus far described.Ankylosing spondylitis is an autoimmune disease affecting vertebral joints.Rheumatoid arthritis,pemphigus vulgaris,diabetes mellitus,and multiple sclerosis are more likely to develop in individuals with certain class II MHC alleles,but these carry much lower relative risks (between 4 and 25).

Individuals with the Class I HLA-B27 Allele Have a 90-Fold