Matching
Match each of the following descriptions in questions with the appropriate disease (A-G).
-Defect in B cell maturation at the pre-B cell stage caused by mutations in the gene encoding the B cell tyrosine kinase (Btk), resulting in undetectable levels of serum Ig
A)X-linked agammaglobulinemia
B)X-linked hyper-IgM syndrome
C)X-linked lymphoproliferative syndrome
D)Bare lymphocyte syndrome
E)Chronic granulomatous disease (CGD)
F)Leukocyte adhesion deficiency-1 (LAD-1)
G)Leukocyte adhesion deficiency-2 (LAD-2)

Question

Quizplus · Accepted Answer

Btk is required for pre-B cell receptor signaling and maturation from pre-B to immature B cells
In females carrying the mutated Btk gene on one X chromosome, the B cells that do mature have all inactivated the X chromosome carrying the mutant allele; thus, these individuals do not show a clinical phenotype
This disease is effectively controlled by injections of pooled gamma globulin.

Matching Match Each of the Following Descriptions in Questions with the the Appropriate