The need for markedly increased amounts of a substance to achieve the desired effect is called

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Tolerance refers to the need for increased amounts of a substance to achieve the desired effect, as the body becomes less responsive to the substance over time. Addiction refers to a psychological or physical dependence on the substance, withdrawal refers to the unpleasant symptoms experienced when discontinuing use of the substance, and compulsion refers to the strong urge or drive to continue using the substance despite negative consequences.

The Need for Markedly Increased Amounts of a Substance to Achieve