The three major criteria for the diagnosis of substance dependence are tolerance, withdrawal, and

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Quizplus · Accepted Answer

Tolerance and withdrawal are physical symptoms of substance use, while compulsive use is the psychological component that characterizes dependence. Criminal activity and psychotic symptoms may be related to substance use, but they are not part of the diagnostic criteria for dependence. Altered brain wave activity may be a neurological consequence of substance use, but it is not a criterion for diagnosis.

The Three Major Criteria for the Diagnosis of Substance Dependence