The translocation that places the transcription factor Tel at the amino terminus of the PDGF receptor converts PDGFR to an oncogene by

Question

Quizplus · Accepted Answer

The fusion of Tel to the amino terminus of the PDGF receptor results in the formation of Tel dimers that produce unregulated signals for proliferation, leading to the activation of downstream signaling pathways that promote cell division and growth. This is the key mechanism by which the PDGFR-Tel fusion protein functions as an oncogene. Options A, C, and D are not consistent with the known functions of this fusion protein.

The Translocation That Places the Transcription Factor Tel at the Amino