The protein encoded by the PTEN gene acts as a tumor suppressor by

Question

Quizplus · Accepted Answer

The PTEN gene encodes for a phosphatase that is responsible for dephosphorylating phosphatidylinositol 3,4,5-bisphosphate (PIP3), which is a key activator of the PI 3 kinase/Akt signaling pathway. Loss or inactivation of PTEN leads to the accumulation of PIP3, which in turn activates Akt and promotes cell survival and proliferation, ultimately contributing to tumor growth. Therefore, the protein encoded by the PTEN gene acts as a tumor suppressor by antagonizing PI 3 kinase/Akt signaling. Options A, B, and D are not accurate representations of the function of PTEN.

The Protein Encoded by the PTEN Gene Acts as a Tumor