During the spindle fiber checkpoint, degradation of _______ allows for separation of the sister chromatids.
A) cyclin B
B) separase
C) cohesin
D) kinetochore

Question

Quizplus · Accepted Answer

The spindle fiber checkpoint is the phase of mitosis during which the cell checks to make sure that all sister chromatids are properly aligned and attached to the spindle fibers. Degradation of cohesin, which holds the sister chromatids together, allows for separation of the sister chromatids and their movement to opposite poles of the cell. Cyclin B is degraded during the metaphase/anaphase transition and is not directly involved in sister chromatid separation. Separase is an enzyme that cleaves cohesin, but it is not degraded during the spindle fiber checkpoint. Kinetochore is a protein complex that attaches spindle fibers to sister chromatids, but it is not degraded during the spindle fiber checkpoint.

During the Spindle Fiber Checkpoint, Degradation of _______ Allows for Separation