A mutation that causes a G-protein to lose its ability to hydrolyze bound GTP would be expected to have constitutively
A) inactive $\beta$$\gamma$subunits.
B) bound $\alpha$$\beta$$\gamma$subunits.
C) active $\alpha$ subunits.
D) inactive $\alpha$ subunits.

Question

Quizplus · Accepted Answer

G-protein hydrolyzes GTP to GDP in order to turn off its signaling activity. Loss of this ability would result in constitutive activation of the protein, meaning it is always signaled on. Therefore, the F1F1F1S1F1F1F10 subunit would be active and signaling constantly.

A Mutation That Causes a G-Protein to Lose Its Ability β\betaβ

A Mutation That Causes a G-Protein to Lose Its Ability $\beta$