Notch is a cell-surface receptor protein that activates transcription when a piece of the Notch molecule is cleaved, enters the nucleus, and activates genes.

Question

Quizplus · Accepted Answer

This describes the basic process of Notch signaling. After the receptor protein binds to its ligand, the intracellular domain of Notch is cleaved and enters the nucleus, where it interacts with transcription factors and activates gene expression.

Notch Is a Cell-Surface Receptor Protein That Activates Transcription When