$\beta$-arrestin binds to phosphorylated G protein-coupled receptors, binding Raf, MEK, and ERK into the complex and linking the G protein-coupled signal pathway to the ERK signal pathway. This is an example of inhibitory crosstalk.

Question

Quizplus · Accepted Answer

The statement is incorrect, as arrestin-mediated activation of the ERK signal pathway is an example of stimulatory crosstalk, not inhibitory.

β\betaβ -Arrestin Binds to Phosphorylated G Protein-Coupled Receptors, Binding Raf, MEK

$\beta$ -Arrestin Binds to Phosphorylated G Protein-Coupled Receptors, Binding Raf, MEK