In the mouse, the total number of heavy chains that can be generated by site-specific recombination events is about A) 600. B) 7,200. C) 10⁵. D) 10⁶.

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Quizplus · Accepted Answer

The total number of heavy chains in mice can be generated through a process called V(D)J recombination, which involves the recombination of variable (V), diversity (D), and joining (J) gene segments. Mice have approximately 200 V segments, 12 D segments, and 4 J segments for the heavy chain. The combination of these segments through recombination events leads to a large number of possible heavy chains. The exact number can vary based on the calculation method, but it's generally accepted to be in the thousands, with 7,200 being a representative estimate for the potential diversity generated through these recombination events.

In the Mouse, the Total Number of Heavy Chains That