Which of the following enzymes serves an important role in both somatic hypermutation and class switch recombination?
A) Helicase
B) Exonuclease
C) DNA glycosylase
D) Activation-induced deaminase

Question

Quizplus · Accepted Answer

Activation-induced deaminase (AID) is a DNA-editing enzyme that introduces mutations, such as point mutations, or double-strand breaks, in the immunoglobulin genes during somatic hypermutation (SHM) and class switch recombination (CSR). AID initiates SHM by deaminating cytosine residues in the immunoglobulin gene sequence and triggering the repair mechanisms to introduce mutations. In CSR, AID deaminates cytosine residues in switch regions, which induces double-strand breaks and allows for the rearrangement of constant region exons. Therefore, AID serves an important role in both processes.

Which of the Following Enzymes Serves an Important Role in Both