Which statement best describes the mechanism of action of miRNAs in blocking expression of proteins?
A) Single-stranded miRNA, in association with the RISC complex, binds to the complementary sequence in the 3ʹ UTR of mRNAs, blocking translation and inducing degradation of the mRNA.
B) The miRNA duplex, in association with the RISC complex, binds to the complementary sequence in the 3ʹ UTR of mRNAs, blocking translation and inducing degradation of the mRNA.
C) Single-stranded miRNA, in association with the RISC complex, binds to the complementary sequence in the 5ʹ UTR of mRNAs, blocking translation and inducing degradation of the mRNA.
D) Single-stranded miRNA, in association with the Drosha and Dicer complex, binds to the complementary sequence in the 3ʹ UTR of mRNAs, blocking translation and inducing degradation of the mRNA.
Correct Answer:
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