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Partial Digestion of Chromatin with Micrococcal Nuclease Was Found to Yield

Question 86

Multiple Choice

Partial digestion of chromatin with micrococcal nuclease was found to yield DNA fragments approximately 200 base pairs long. What accounts for this phenomenon?


A) The low pH environment of the nucleus renders the nuclease able to cut only in 200-base-pair increments.
B) This result suggests that the binding of proteins to DNA in chromatin protects regions of DNA from nuclease digestion.
C) This is a random phenomenon, and its significance is unknown.
D) The nuclease cleaves at specific DNA sequences that occur every 200 base pairs in the genome.

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