In the chromatin around centromeres, nucleosomes are present that have a unique structure in which the core protein _______ is replaced by _______, and this variant of the nucleosome is required for protein assembly at the kinetochore.

Question

Quizplus · Accepted Answer

The unique nucleosomes in the chromatin around centromeres contain a variant of the core protein histone H3, called CENP-A. This variant is required for protein assembly at the kinetochore. Histone H5 is not a known variant and histone H1 is a linker histone, not a core histone, and is not typically found in nucleosomes around centromeres.

In the Chromatin Around Centromeres, Nucleosomes Are Present That Have