First-generation antipsychotics work primarily by restricting the availability of the neurotransmitter dopamine, either by blocking dopamine receptors entirely or by inhibiting the neurotransmitter's release

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First-generation antipsychotics, also known as typical antipsychotics, primarily act by blocking dopamine receptors or reducing dopamine release in the brain. This is why they are also referred to as dopamine antagonists.

First-Generation Antipsychotics Work Primarily by Restricting the Availability of the Neurotransmitter