How do the newer drugs valbenazine and deutetrabenazine act to reduce tardive dyskinesia in patients taking neuroleptics?
A) They inhibit the enzyme catechol-O-methyltransferase (COMT) , which degrades DA in the synapse, halting its signaling.
B) They enhance glutamate activity at NMDA receptors.
C) As muscarinic ACh receptor antagonists, they reduce excess ACh activity.
D) They reduce the amount of DA that can be released into the synapse by inhibiting vesicular monoamine transporter, subtype 2 (VMAT2) .
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