The Time Course of Effectiveness for Antipsychotic Medications Has Been

The time course of effectiveness for antipsychotic medications has been explained by all of the following observations except that

A) dopamine receptor blockade is not directly linked to clinical improvement.
B) chronic dopamine autoreceptor blockade may result in receptor supersensitivity, and hence decreased dopamine turnover.
C) a depolarization block can occur in response to increased dopamine turnover, which results from the initial antipsychotic drug blockade of receptors.
D) over time, antipsychotics decrease their binding to DA receptors and begin to act at other receptor populations.