Both inhibiting the enzyme catechol-O-methyltransferase (COMT) and the norepinephrine transporter (NET) inhibitor drug atomoxetine are strategies used to treat _______ by _______.

Question

Quizplus · Accepted Answer

Inhibiting COMT increases the level of dopamine (DA) in the prefrontal cortex (PFC), improving cognitive symptoms. NET inhibitors also increase DA levels in the PFC by preventing the reuptake of norepinephrine (NE), which then blocks the breakdown of DA. This is also effective in treating cognitive symptoms. Tremors are not treated by these strategies, and reducing glutamate levels in the PFC is not a relevant treatment approach.

Both Inhibiting the Enzyme Catechol-O-Methyltransferase (COMT) and the Norepinephrine Transporter