A secondary consequence of NMDA receptor antagonism is _______ presynaptic glutamate release, which may result from preferential _______ of receptors on inhibitory GABAergic interneurons that innervate the cortical pyramidal neurons.

Question

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NMDA receptor antagonism leads to increased presynaptic glutamate release because it preferentially blocks receptors on inhibitory GABAergic interneurons. This blockade reduces the inhibitory effect on cortical pyramidal neurons, indirectly increasing glutamate release.

A Secondary Consequence of NMDA Receptor Antagonism Is _______ Presynaptic