In Animal Models, Blockade of _______ Reduces Stress-Induced Relapse and Withdrawal-Induced

In animal models, blockade of _______ reduces stress-induced relapse and withdrawal-induced alcohol consumption, but this approach hasn't worked in humans because _______.

A) opioid receptors; people will not take the medication required for the test
B) NK1R; humans do not possess this receptor type
C) CRF₁ receptors; these antagonists do not cross the blood-brain barrier
D) glutamate receptors; stress is not a major factor in human alcohol consumption