In order to study the effects of serotonin depletion in rodent studies,
A) tryptophan hydroxylase is inhibited by injection of para-chlorophenylalanine (PCPA).
B) tryptophan hydroxylase is stimulated by injection of para-chlorophenylalanine (PCPA).
C) animals are fed a high carbohydrate, low protein diet.
D) insulin is injected to alter the ratio of amino acids in the blood.

Question

Quizplus · Accepted Answer

Tryptophan hydroxylase is the enzyme responsible for the conversion of tryptophan into serotonin. Inhibition of this enzyme with para-chlorophenylalanine leads to a depletion of serotonin in the brain, allowing researchers to study the effects of serotonin on behavior and physiological processes.

In Order to Study the Effects of Serotonin Depletion in Rodent