A mouse is tested in the elevated plus-maze and shows extreme anxiety compared to other mice. From this observation you surmise that this mouse likely A) is a 5-HT₄-knockout mouse. B) has been treated with a selective 5-HT_2C agonist. C) is a 5-HT_1A-knockout mouse. D) has been treated with a 5-HT_1A receptor agonist.

Question

Quizplus · Accepted Answer

5-HT_1A receptors are associated with anxiety regulation. A knockout mouse lacking these receptors would likely show increased anxiety.

A Mouse Is Tested in the Elevated Plus-Maze and Shows