First-pass metabolism occurs when drugs are taken

Question

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First-pass metabolism occurs when drugs are taken orally, as they are absorbed through the gastrointestinal tract and pass through the liver before reaching systemic circulation, where they may be metabolized before reaching their intended target site. Drugs administered through other routes such as intravenous, subcutaneous or nasal do not pass through the liver and undergo minimal to no first-pass metabolism.

First-Pass Metabolism Occurs When Drugs Are Taken